Problem of chronic endometritis in cows and ways to solve it

Sergey Shabunin,Ivan Bondarev,Vitaly Mikhalev,Igor Tolkachev,Anatoly Stekolnikov,D Fayzrakhmanov,F Nezhmetdinova,R Shaydullin,B Ziganshin

doi:10.1051/bioconf/20201700101

Abstract

Chronic endometritis is diagnosed on average in 18.1 % of infertile cows. With chronic endometritis, the uterus has a pronounced cavity of 18.4±0.9 mm (11–35 mm), while the wall thickness of the uterus is on average 8.7±0.37 mm. Morphometrically chronic endometritis is characterized by a decrease in the fraction of functionally active elements of the endometrium (integument epithelium, uterine glands, blood vessels) to 12.17 %. In the development of chronic endometritis, cows compared with clinically healthy animals showed an increase in leukocyte content by 12.2 %, monocytes by 2.5 times, creatinine by 29.7 %, average molecular peptides by 25.0 %, and endogenous intoxication index by 25.4 %, circulating immune complexes by 38.5 %, with a decrease in the bactericidal and lysozyme activity of blood serum, respectively by 10.7 and 12.9 % and phagocytic activity of leukocytes by 12.4 %. The effectiveness of the application of the developed method for the treatment of chronic endometritis, involving the use of aminoseleton five times with a 72-hour interval at a dose of 30, 35, 40, 45 and 50 ml, magestrofan on the 1st and 13th days at a dose of 2 ml, uterotone on 3rd, 4th and 5th days at a dose of 10 ml and intrauterine administration of primalact on 1st-3rd days at a dose of 20 ml, is 88.0 %. Recovery of animals after the treatment is accompanied by a decrease in the inflammatory response, endogenous intoxication, normalization of liver and kidneys, an increase in overall non-specific resistance and a decrease in uterine microbial contamination.

Highlights

At the present stage of development of dairy animal husbandry, one of the constraining factors is the gynecological diseases of cows, which include chronic endometritis registered in 15.0–67.0 % of infertile animals [1, 2]
The nonspecific use of chemotherapeutic agents in the treatment of acute postpartum endometritis leads to an increase in the drug resistance of microorganisms, weakening of protective mechanisms, spontaneous mutations, causing the appearance of genetically resistant populations, which complicates the treatment, and chemotherapy becomes a link of etiopathogenesis of chronic endometritis of cows [7, 8]
Clinical-echographic studies have shown that chronic endometritis is characterized by an increase in the size of the uterus by 1.5–2.0 times, a weakly expressed response to massage, and an elastic consistency

Summary

Introduction

At the present stage of development of dairy animal husbandry, one of the constraining factors is the gynecological diseases of cows, which include chronic endometritis registered in 15.0–67.0 % of infertile animals [1, 2]. Highly productive cows have increased the frequency of inflammatory processes caused by opportunistic microorganisms First of all, this is due to the introduction of broad-spectrum antibiotics into veterinary practice, which led to noticeable disturbances in the environmental relationships between a macroorganism and its microflora [5, 6]. And ineffective treatment of chronic endometritis in cows leads to impaired reproductive function, decreased milk productivity and premature culling [9, 10]. In this regard, the study of the clinical and pathogenetic features of the development of chronic endometritis in dairy cows and the development of methods for its pharmacotherapy are high on the agenda and require detailed study

Materials and methods

Results and discussion

Conclusion