Problem in the diagnosis of leukemia.

Abstract

Article1 May 1957PROBLEM IN THE DIAGNOSIS OF LEUKEMIAMANUEL J. ROWEN, M.D., F.A.C.P.MANUEL J. ROWEN, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-46-5-907 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptINTRODUCTIONLeukemia as a clinical entity has been recognized for many years. It is identified by various combinations of adenopathy, hepatosplenomegaly, anemia and varied bleeding tendencies, as well as by other factors such as infection and necrosis. When the disease is full-blown clinically the bone marrow findings should be conclusive. Frequently they are not performed because of the obvious clinical picture and the appearance of the peripheral blood. According to Wintrobe,1"Hyperplasia is usually diffuse and widespread throughout the marrow spaces"; however, it is conceivable that it may not involve all of the marrow spaces at all stages of the...Bibliography1. Wintrobe MM: Clinical hematology, 3d Ed., 1952, Lea and Febiger, Philadelphia. Google Scholar2. BlockJacobsonBethard MLDWF: Preleukemic acute human leukemia, J. A. M. A. 152: 1018-1028, 1953. CrossrefMedlineGoogle Scholar3. AndreMartyRespeMorichman-Beuchant LJRJ: A case of acute leukemia preceded by neutropenia, of 18 months duration, Bull. et mém. Soc. méd. d. hôp. de Paris 69: 417-421, 1953. Google Scholar4. MeachamWeissberger GCAS: Early atypical manifestations of leukemia, J. Lab. and Clin. Med. 42: 923-924, 1953. Google Scholar5. BernardTubianaMathe JMG: Discrepancies between the state of the blood and that of the hematopoietic organs in the leukemias, Semaine d. hôp. Paris 28: 3726-3735, 1952. Google Scholar6. DanopoulosAngelopoulos EB: Der extramedulläre Beginn der akuten Leukämien; Beobachtungen und Schlüsse bei 3 eigenen Fällen, Med. Klin. 49: 1947-1950, 1954. MedlineGoogle Scholar7. DreyfusBessis BM: Acute leukemia preceded by myeloid aplasia, Sang 25: 787-797, 1954. MedlineGoogle Scholar8. BernardBoron JM: The preleucoblastic anemias of acute leukemias, Sang 25: 797-825, 1954. MedlineGoogle Scholar9. Erf LA: Leukemia—theory and therapy, Seminar 16: 2-6, 1945. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Elizabeth, New Jersey*Received for publication May 18, 1956.From the Department of Medicine, Alexian Brothers Hospital, St. Elizabeths Hospital, Elizabeth, New Jersey.Requests for reprints should be addressed to Manuel J. Rowen, M.D.133 West Jersey Street, Elizabeth, New Jersey. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byHypoplastic Acute Myelogenous LeukaemiaPreleukemiaAcute myeloid leukemia following seven years of aplastic anemia induced by chloramphenicolSmoldering Acute Leukemia 1 May 1957Volume 46, Issue 5Page: 907-914KeywordsAnemiaBloodBone marrowHemorrhageHepatosplenomegalyHospital medicineNecrosis Issue Published: 1 May 1957 PDF downloadLoading ...