Probiotics Supplementation Improves Intestinal Permeability, Obesity Index and Metabolic Biomarkers in Elderly Thai Subjects: A Randomized Controlled Trial.

Chaiyavat Chaiyasut,Narissara Lailerd,Khontaros Chaiyasut,Phakkharawat Sittiprapaporn,Sartjin Peerajan,Pranom Fukngoen,Bhagavathi Sundaram Sivamaruthi,Manee Saelee,Sasithorn Sirilun,Periyanaina Kesika,Suchanat Khongtan

doi:10.3390/foods11030268

Chaiyavat Chaiyasut, Narissara Lailerd + Show 9 more

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https://doi.org/10.3390/foods11030268

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Abstract

Intestinal integrity prevents the diffusion of allergens, toxins, and pathogens from the gastrointestinal lumen into the tissue and the circulatory system. Damage in intestinal integrity may cause mild to serious health issues, such as inflammation, gastrointestinal disorders, neurological diseases, and neurodegenerative disorders. Thus, maintaining a healthy intestinal barrier function is essential to sustain health. Probiotics are known for their ability to protect and restore intestinal permeability in vitro and in vivo. The multi-strain probiotics are more efficient than that of a single strain in terms of their protective efficacy. Therefore, the present study was planned and implemented to study the supplementation of probiotic mix (Lactobacillus paracasei HII01, Bifidobacterium breve, and Bifidobacterium longum) on intestinal permeability, lipid profile, obesity index and metabolic biomarkers in elderly Thai subjects. The results revealed that the supplementation of studied probiotics improved the intestinal barrier function (up to 48%), significantly increasing the high-density lipoprotein (HDL)-cholesterol. Moreover, the intervention improved obesity-related anthropometric biomarkers and short-chain fatty acid levels in human subjects. The current study strongly recommends further extended research to confirm the beneficial effect of probiotics, which may pave the way to formulate probiotic-based health supplements to adjuvant the treatment of several metabolic diseases.

Highlights

This article is an open access articleThe most important protective function of the intestinal epithelium is the “barrier function,” which prevents the diffusion of allergens, toxins, and pathogens from the gastrointestinal lumen into the tissue and the circulatory system [1,2]
A total of 60 subjects were screened, and 48 subjects were selected for randomization
No significant changes were observed in TC, TG, LDL-C, and hsCRP values after the study period in the probiotic-treated group (Table 4). These results indicated that the studied multispecies probiotic mix improved the lipid profile and obesity-related biomarkers in studied human subjects

Summary

Introduction

This article is an open access articleThe most important protective function of the intestinal epithelium is the “barrier function,” which prevents the diffusion of allergens, toxins, and pathogens from the gastrointestinal lumen into the tissue and the circulatory system [1,2]. The imbalance of gastrointestinal microbiota and its function may cause interruption of the tight junctions, which provokes intestinal permeability [4]. Bacterial debris, endotoxins such as lipopolysaccharides (LPS), and other microbial metabolites breach the circulatory system and reach internal organs, which can cause mild to serious health issues such as inflammation, gastrointestinal disorders, neurological diseases, and neurodegenerative disorders [5,6]. The gastrointestinal tract, especially the gut, has a complex and bidirectional communication with the central nervous system (gut–brain axis) that communicates in health and diseases [7]. The disturbance in gut microbiota might affect neurological functions and vice versa [8]. The loss of intestinal permeability might cause various neurological diseases [9,10]

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