Probiotics for caries prevention during orthodontic treatment

Abstract

Relevance. The article analyzes the literature data on the use of probiotics for caries prevention. It presents clinical study results of the effectiveness of the DentoBLIS probiotic with Str. Salivarius M18 strain and vitamin D during orthodontic treatment in adolescents. Materials and methods. We conducted an open single-centre comparative study on the DentoBLIS one-month administration to 40 adolescents with fixed orthodontic appliances and dental caries. Results. The DentoBLIS one-month use demonstrated a decrease in the oral hygiene index by 16.45%, braces hygiene index – by 26.58%, the Muehlemann-Cowell index reduction by 16.67%, and an anti-halitosis effect – decrease in halitosis severity according to the VAS by 24.92%, according to the concentration of volatile sulfur compounds (VSCs) by 34.48%. DentoBLIS affects the saliva biochemical parameters, reflecting the microbiota condition: a significant increase in pH from 6.88 ± 0.04 to 6.95 ± 0.04, a decrease in saliva protein level from 5.01 ± 0.48 to 3.68 ± 0.44 g/l, decrease in glucose level from 0.45 ± 0.07 to 0.29 ± 0.02 mmol /l and GOT from 10.87 ± 1.18 to 7.73 ± 0.94 U/l. Conclusion. The DentoBLIS probiotic reduces plaque formation, gingival bleeding and halitosis severity in adolescents with dental caries during orthodontic treatment. Biochemical analysis revealed changes in some parameters of mixed saliva after the DentoBLIS use, which indicates a positive effect of the probiotic on the oral microbiota.