Abstract
Aim:Nonalcoholic fatty liver disease (NAFLD) is probably the most common liver disorder in the world. A subgroup of NAFLD patients is characterized by injury to the hepatocytes and inflammation in addition to excessive fat (steatohepatitis), the latter condition is nominated nonalcoholic steatohepatitis (NASH). This work aimed to evaluate the role of probiotics on the outcome of NASH in patients admitted to the Tropical Medicine Department, Faculty of Medicine, Zagazig University (inpatients and outpatients).Materials and methods:This study was performed on 30 patients (17 males and 13 females), with body mass index from 30 to 35 and average age of 44 years with bright fatty liver in ultrasonography and raised alanine transaminase (ALT) and aspartate transaminase (AST) and positive liver biopsy findings. The patients were divided into group I (case group) that included 15 patients who received probiotics and group II of 15 patients as control group who did not receive probiotics; the study was conducted between November 2014 and April 2016. Clinical assessment, laboratory evaluation, pelvic-abdominal ultrasound, and liver biopsy of all cases were carried out.Results:In this study, there was significant decrease in liver enzymes (ALT and AST) and no statistically significant other laboratory findings. Also there was relief for dyspepsia in some patients.Conclusion:Probiotics treatment is effective, safe, well-tolerated, inexpensive, appropriate for long-term use, and optimally, works at multiple levels to downregulate inflammatory mediators, and therefore, probiotics could be an option in the treatment of NASH.How to cite this article: Monem SMA. Probiotic Therapy in Patients with Nonalcoholic Steatohepatitis in Zagazig University Hospitals. Euroasian J Hepato-Gastroenterol 2017;7(1):101-106.
Highlights
IntroductionNonalcoholic fatty liver disease (NAFLD) is a state defined by extreme fat accumulation in the form of triglycerides (steatosis) in the liver (more than 5% of liver cells histologically)
Nonalcoholic fatty liver disease (NAFLD) is a state defined by extreme fat accumulation in the form of triglycerides in the liver
Probiotics treatment is effective, safe, well-tolerated, inexpensive, appropriate for long-term use, and optimally, works at multiple levels to downregulate inflammatory mediators, and probiotics could be an option in the treatment of nonalcoholic steatohepatitis (NASH)
Summary
Nonalcoholic fatty liver disease (NAFLD) is a state defined by extreme fat accumulation in the form of triglycerides (steatosis) in the liver (more than 5% of liver cells histologically). It is considered nowadays as one of the most frequent causes of abnormal liver tests all over the world, and it ranges from simple steatosis to advanced fibrosis and cirrhosis. A subgroup of NAFLD patients were characterized by injury to the hepatocytes and inflammation in addition to excessive fat (steatohepatitis) The latter condition, nominated nonalcoholic steatohepatitis (NASH), is practically indistinguishable histologically from alcoholic steatohepatitis, and it is characterized by fatty infiltration of the liver with different degrees of inflammation, necrosis, and fibrosis, almost identical to those of alcoholic liver disease; without significant alcohol ingestion.[1]. The prevalence of NAFLD ranges from 10 to 24% of the general population, while NASH affects about 3% of the lean population and nearly half of morbidly obese people.[2]
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