Abstract
ABSTRACT This study aimed to investigate the effect of Lactobacillus plantarum DPP8 and Lactobacillus acidophilus C7282 in feed supplementation on growth performance, Salmonella invasion, inflammation, and mediating signaling in broilers infected with Salmonella Typhimurium (S. Typhimurium). A total of 240 broilers at day old were randomly allocated into four groups, orally infected with S. Typhimurium and supplemented with individual or combined Lactobacilli DPP8 and C7282 at doses of 0 (control), 1010 (individual), or 2.0 × 1010 (combination) cfu/kg of diet for 21 d. The results showed that supplementing Lactobacilli improved (p<0.05) feed intake and body weight gain and decreased (p<0.05) S. Typhimurium load in the caecum, harder gland, spleen and bursa of Fabricius. Also, the supplements decreased (p<0.05) interleukin (1β/2/4), tumor necrosis factor α and interferon γ in the serum, enhanced (p<0.05) interleukin 10, and downregulated gene expressions of inflammatory mediators including Janus kinase (Jak2/3), signal transducer and activator of transcription protein (STAT3/4/5/6) in the intestinal mucosa. In contrast, diets containing DPP8 exhibited greater effects on the inhibition of the pathogen and inflammatory response than C7282. The obtained data suggest that Lactobacilli C7282 and DPP8 can be used as feed additives to inhibit colonization and translocation of S. Typhimurium and inflammatory responses via downregulating Jak/STAT signaling in broilers.
Highlights
Salmonella infection is one of the world’s most leading epidemic diseases and poses a great threat to animal production and public health (Dar et al, 2017; Chen et al, 2018)
On the 21st d post administration, the broilers in the control treatment showed worse (p
The findings indicate that individual or combined C7282 and DPP8 can attenuate the negative effect of S
Summary
Salmonella infection is one of the world’s most leading epidemic diseases and poses a great threat to animal production and public health (Dar et al, 2017; Chen et al, 2018). A primary source for this foodborne diseases, is most susceptible to Salmonella strains especially Salmonella Typhimurium Typhimurium) (Ding et al, 2018; Liu et al, 2019). Lactobacilli has long been used as a health-promoting agent in prevention or treatment of enteric infection and inflammatory diseases and its possible action mechanisms are involved in the modulation of intestinal barrier, defensin, lactic acid production and interactions with hosts and pathogens during inflammatory initiation and progress (Liu et al, 2017, 2018a,c; Wang et al, 2019a; Deng et al, 2020a,b). Lactobacillus rhamnosus GG elevated gut epithelial leptin levels which acted as a eRBCA-2020-1328
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