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Abstract
TNBS-induced ulcerative colitis was evaluatedusingBacillus licheniformisMCC 2514 (B. licheniformis) andBifidobacterium breve NCIM 5671 (Bf. breve)as immune modulators.The study aims to analyze probiotic efficiency of ulcerative colitis induced by TNBS in Wistar rats. The tumor-like structure was found in the colon of TNBS inflammation-induced rats. Nitric oxide production was inhibited by about65.2% fed with combination of bacteria andC-reactive protein, and decreased by 12% and 10.8% upon supplementingB. licheniformisandBf. breveagainst the TNBS-treated rats, respectively. Liver damage was observed in the TNBS-treated rats; addition of probiotic bacteria reduced SGPT (75.4%) and SGOT (42.5%).On TNBS treatment, the transcriptional factor responsible for Th2 cell immune response (GATA3) was analyzed, and the elevation in gene expression (5.31-fold) was found. The FOXP-3 responsible for T-regulatory cells was expressed about 0.91-fold upon the treatment with a combination of bacteria. The expression of antioxidant genes such as iNOS (1.11-fold),GPx (1.29-fold), and PON1 (1.48-fold)has been increased when compared with that of the TNBS-treated group. The cytokines specific to Th2-driven immune response, such as IL-4, IL-5, and TNF-α, were reduced upon feeding the bacteria. It is observed that theB. licheniformisandBf. breveused in the study have reduced Th2-driven immune response.
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