Probing the Structural and Antimicrobial Study on a Sol–Gel Derived Velosef-Loaded Bioactive Calcium Magneso-Silicate Xerogel

Abstract

The nature of the opening silicate- based surface affects the chemical interaction, spectroscopic and antimicrobial efficiency. The aim of this approach was to evaluate the spectroscopic properties and the antimicrobial activity of Velosef-loaded bioactive calcium magneso-silicate xerogel (CMS) prepared by green sol gel method. Loading of Velosef drug into the controlled calcium magneso-silicate xerogel was analyzed by XRD, HR-TEM, FE-SEM, and UV-Vis-absorption spectra. The particle distribution and surface morphological analysis indicated the establishment of calcium magneso-silicate/Velosef xero-gels. The UV-absorption exposed an increase in the refractive index and the band gap values of the xerogels with increasing Velosef content. The prepared calcium magneso-silicate/Volesef loaded xerogel samples exerted higher antimicrobial activity versus the three tested model microorganisms. The highest antimicrobial efficiency was recorded in case of Candida albicans at concentration of 0.03 wt% from Volesef loaded nanocomposites (37 mm), whereas the lower antimicrobial efficiency (26 mm) was recorded versus B. mycoides at the same concentration. These results appears that the calcium magneso-silicate xerogel-based to be a promising nano-structures material for spectroscopic and bio-applications.