Abstract
We have used liquid-gating to investigate the sensitivity of nanowire (NW)-basedbiosensors for application in the field of ultrasensitive biodetection. Wedeveloped an equivalent capacitance model of the biosensor system toexplore the dependence of the sensitivity on the liquid-gate voltage (Vlg), which was influenced by capacitive competition between the NW capacitance and thethin oxide capacitance. NW biosensors with highest sensitivity were obtained when weoperated the device in the subthreshold regime while applying an appropriate value ofVlg; the influence of leakage paths through the ionic solutions led, however, to significantsensitivity degradation and narrowed the operating window in the subthreshold regime.
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