Probing the mechanisms of adaptation of macaque inferotemporal neurons with optogenetics

Abstract

Event Abstract Back to Event Probing the mechanisms of adaptation of macaque inferotemporal neurons with optogenetics Francesco Fabbrini1*, Chris Van Den Haute1, Marina De Vitis1, Veerle Baekelandt1, Wim Vanduffel1 and Rufin Vogels1 1 KU Leuven, Belgium Neurons in macaque inferior temporal (IT) cortex, the end stage of the ventral visual stream, show a decrease in the response with stimulus repetition, known as repetition suppression. Several mechanisms have been proposed to explain this form of adaptation in IT, from firing-rate dependent fatigue to influences of other brain areas. We recorded spiking activity from IT cortex of two monkeys while simultaneously stimulating optically neurons previously transduced with a depolarizing opsin, ChrimsonR, and measured the effect of stimulation on their responses. Photo-stimulation could lead to both an increase and a suppression of a neuron’s firing rate. In the first case, preceding photo-stimulation had no effect on the response to a subsequent visual stimulus with a typical contrast; we observed small suppression of the response to repeated photo-stimulation or when a low-contrast visual stimulus followed photo-stimulation. Units suppressed during photo-stimulation showed a strongly suppressed response to simultaneously presented visual and photo-stimulation (compound stimulus). Using this compound stimulus as adapter produced little or no effect on the response to a subsequent visual stimulus compared with repetition of the same visual stimulus. Together, these results suggest only a small if any contribution of firing-rate dependent mechanisms to repetition suppression in IT. Keywords: Neurophysiology, optogenetic, visual adaptation, Nonhuman primate (NHP), temporal cortex Conference: 13th National Congress of the Belgian Society for Neuroscience , Brussels, Belgium, 24 May - 24 May, 2019. Presentation Type: Poster presentation Topic: Behavioral/Systems Neuroscience Citation: Fabbrini F, Van Den Haute C, De Vitis M, Baekelandt V, Vanduffel W and Vogels R (2019). Probing the mechanisms of adaptation of macaque inferotemporal neurons with optogenetics. Front. Neurosci. Conference Abstract: 13th National Congress of the Belgian Society for Neuroscience . doi: 10.3389/conf.fnins.2019.96.00091 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 10 Apr 2019; Published Online: 27 Sep 2019. * Correspondence: Mx. Francesco Fabbrini, KU Leuven, Leuven, Belgium, francesco.fabbrini@kuleuven.be Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Francesco Fabbrini Chris Van Den Haute Marina De Vitis Veerle Baekelandt Wim Vanduffel Rufin Vogels Google Francesco Fabbrini Chris Van Den Haute Marina De Vitis Veerle Baekelandt Wim Vanduffel Rufin Vogels Google Scholar Francesco Fabbrini Chris Van Den Haute Marina De Vitis Veerle Baekelandt Wim Vanduffel Rufin Vogels PubMed Francesco Fabbrini Chris Van Den Haute Marina De Vitis Veerle Baekelandt Wim Vanduffel Rufin Vogels Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.