Probing T-cell Infiltration in Tumors.

Abstract

A recent study suggests that the absence of infiltrating T cells in some tumors is not because they lack neoantigens. Comparing melanoma samples with and without T cell-driven inflammation, researchers found no differences in mutational load and neoantigen density. Noninflamed tumors, however, lacked a subset of dendritic cells that helps promote T-cell infiltration.