Abstract
Jin Zhang, Departments of Pharmacology & Molecular Sciences, Neuroscience and Oncology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205The complexity and specificity of many forms of signal transduction are widely suspected to require spatial microcompartmentation and dynamic modulation of the activities of signaling molecules, such as protein kinases, phosphatases and second messengers. I will present studies where we combined genetically encoded fluorescent biosensors, targeted biochemical perturbations, mathematic modeling and superresolution imaging to probe the spatiotemporal regulation of signaling molecules such as cAMP, Protein Kinase A, calcineurin and Protein Kinase B.
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