Abstract
In this manuscript we present novel MRI approaches to dissecting axon vs. myelin abnormalities in psychiatric disorders. Existing DTI approaches are not able to provide specific information on these subcellular elements but novel approaches are beginning to do so. We review two approaches (magnetization transfer ratio—MTR; and diffusion tensor spectroscopy—DTS) and the theoretical framework for interpreting data derived from these approaches. Work is ongoing to collect data that will answer some relevant questions using these techniques in schizophrenia and related conditions.
Highlights
Mental illnesses are common, debilitating, and at times fatal (Kessler et al, 2005)
We review two approaches and the theoretical framework for interpreting data derived from these approaches
0.55 ± 0.15 0.58 ± 0.18 0.60 ± 0.10 different information offered by diffusion tensor spectroscopy (DTS)—the diffusion properties of NAA are dependent on axon geometry and this information is complementary to the water diffusion information garnered using diffusion tensor imaging (DTI)
Summary
Probing myelin and axon abnormalities separately in psychiatric disorders using MRI techniques. Reviewed by: Kang Sim, Institute of Mental Health, Singapore Matthew D. Medical College of Wisconsin, USA Gabriel A. De Erausquin, University of South Florida, USA. In this manuscript we present novel MRI approaches to dissecting axon vs myelin abnormalities in psychiatric disorders. Existing DTI approaches are not able to provide specific information on these subcellular elements but novel approaches are beginning to do so. We review two approaches (magnetization transfer ratio—MTR; and diffusion tensor spectroscopy—DTS) and the theoretical framework for interpreting data derived from these approaches. Work is ongoing to collect data that will answer some relevant questions using these techniques in schizophrenia and related conditions
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