Probing Membrane Protein Interactions by 19 F Solid-State NMR

Abstract

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The 19F nucleus has a high gyromagnetic ratio that is comparable to that of proton. Due to its high sensitivity and low background in the biological systems, 19F labeling has emerged as an attractive approach in biological solid-state NMR studies. In this review, we summarized the widely used 19F-labeling strategies, 19F solid-state NMR spectroscopy techniques to probe membrane protein interactions, and the recent applications of 19F solid-state NMR in characterizing of membrane proteins. The limitations of 19F solid-state NMR were also highlighted.