Abstract
Abstract The complex formation of amantadine hydrochloride with 18-crown-6 was studied in methanol solution by surface tension, conductivity and IR study. The limiting apparent molar volume data have been used to characterize the interaction between drug molecule (amantadine hydrochloride) and 18-crown-6 in the experimental ternary solution systems. A conductance study concerning the interaction between cationic organic ammonium ions amantadine with 18-crown-6 in methanol solution has been carried out at different temperatures. The formation constant (logK f ) of the resulting 1:1 complex at various temperatures was determined from the conductivity study. The enthalpy (ΔH 0) entropy (ΔS 0) and free energy change (ΔG 0) of the complexation reaction was determined from the temperature dependence of the formation constant.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
