Abstract
Somatic mutations may contribute to neuronal functional diversity and the unexplained burden of neurological disease, but the extent of genomic diversity among individual neurons is unclear. Evrony et al. amplified the genomes of single neurons from the human brain and assessed the frequency with which somatic LINE-1 (L1) retrotransposon insertions occur. Some previous studies had found frequent L1 retrotransposition in the human brain, but Evrony et al. found < 1 somatic L1 insertion per neuron in the cortex and caudate nucleus, suggesting that L1 is not a major effector of neuronal diversity in these brain regions.
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