Abstract

The action of probenecid (probenecid is an agent known to inhibit the release of cyclic AMP by pigeon erythrocytes) on the urinary bladder of Rana esculenta has been investigated. Conspicuous modifications in the responses of the bladder to various compounds were observed; surprisingly, hydrosmotic responses to exogenous cyclic AMP and theophylline were strongly enhanced, although the response to neuropeptides was inhibited. A single primary action of probenecid on cyclic AMP transfers is suggested as a tentative explanation of these results.

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