Probe tip contact force and bowel distension affect crypt morphology during confocal endomicroscopy

Abstract

IntroductionEndoscopic probe-based confocal endomicroscopy (pCLE) provides 500 μm diameter en-face, cellular resolution, ‘optical biopsies’ of the gastrointestinal mucosal surface. Many burgeoning classification criteria incorporate crypt morphology analysis: hyperplastic colonic polyps...