Probable localization of synaptic inputs evoking generation of slow inhibitory postsynaptic potentials in pyramidal neurons: Simulation studies

Abstract

In computer-experiments using the interactive program, CRONA, and using data from natural experiments that measured the reversal potential of slow (long-term) inhibitory postsynaptic potentials (slow IPSPs), we determined the probable location of the region of potassium-conducting synapses that are responsible for their generation. Parameters such as the geometric dimensions of neuronal dendritic branches and the intracellular concentration of K+ were studied for their effect on the determination of this region. It is concluded that these synaptic inputs are non-somatic, and that allowing for the variability of the initial parameters they probably lie on the apical dendrites at a distance between 110 and 460 µm from the soma.