Abstract
BackgroundLevetiracetam (LEV) is an antiepileptic drug with a favorable tolerability and safety profile with little or no effect on liver function.Case presentationHere, we reported an epileptic pediatric patient who developed a significant elevation in serum alkaline phosphatase level (ALP) during LEV monotherapy. Moreover, the serum ALP level was surprisingly decreased to normal after LEV discontinuation. The Naranjo Adverse Drug Reaction Probability Scale score was 6, indicating firstly LEV was a probable cause for the increased serum ALP.ConclusionsCautious usage and concerns of the LEV-associated potential ALP elevation should be considered when levetiracetam is prescribed to epilepsy patients, especially pediatric patients.
Highlights
Levetiracetam (LEV) is an antiepileptic drug with a favorable tolerability and safety profile with little or no effect on liver function
Levetiracetam (LEV), structurally similar to the nootropic drug piracetam, is an anticonvulsant medication used for epilepsy treatment
It has been approved by the US Food and Drug Administration as adjunctive therapy for partial seizures in adult and children over 4 years of age with favorable tolerability and safety [1,2]
Summary
Levetiracetam (LEV), structurally similar to the nootropic drug piracetam, is an anticonvulsant medication used for epilepsy treatment It has been approved by the US Food and Drug Administration as adjunctive therapy for partial seizures in adult and children over 4 years of age with favorable tolerability and safety [1,2]. Five months after LEV treatment, an elevation of serum ALP level (1613 U/L) was accidentally found from a periodical blood biochemistry test without any other abnormalities. Six months follow-up indicated that the patient was fully recovered, manifesting no recurrent seizure attack or liver function abnormality She was well developed and nourished during that period, observing from her height, weight, and body mass index. A score of 6 was obtained (Additional file 2), demonstrating LEV was a “probable” cause for the serum ALP elevation, and LEV even possibly led to liver function abnormality LEV rechallenge was not executed in this patient
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