Abstract
As Histoplasma capsulatum is capable of systemic dissemination, disease due to this agent may have protean manifestations including cardiovascular involvement. Such involvement has been reported as follows: pericardial calcification, 1-3 fibrocalcific pericarditis with constriction, 4 superior vena caval obstruction, 5 endocarditis, 6 electrocardiographic evidence of pericarditis with positive histoplasmin skin test, 7 and at least six cases of acute pericarditis with effusion. 5,8-12 The present report adds another case of acute pericarditis with effusion and recurrence probably due to H capsulatum. Report of Case A 17-year-old white man entered the University of Illinois Research and Educational Hospitals on April 8, 1960. On March 25 and March 26, I960, he had noted a mild sore throat without constitutional symptoms. At 5 am on March 27 he awakened with sharp, tight anterior chest pain accompanied by dyspnea and diaphoresis. After emergency admission to another hospital, he was treated with methylprednisolone, 4 mg t.i.d., symptomatic drugs for pain, and bed
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