Probability of spontaneously resolvable conglomerates for racemic acid/racemic amine salts predicted on the basis of the results of diastereomeric resolutions

Abstract

The salts of racemic acids with racemic amines, of which the enantiopure component is a good resolving agent for the corresponding counterpart in diastereomeric resolution, have an extremely high tendency to be conglomerates: the results of diastereomeric resolutions are highly informative for the prediction of conglomerates, which can be enantioseparated by preferential crystallization developed independently from diastereomeric resolution over one and a half centuries.