Probability of cell hits in selected organs and tissues by high-let particles at the ISS orbit

Abstract

The fluence of high-LET particles (HLP) with LET ∞·H 2O greater than 15 keV μm −1 in selected organs and tissues were measured with plastic nuclear track detectors using a life-size human phantom on the 9 th Shuttle-Mir Mission (STS-91). The planar-track fluence of HLP during the 9.8-day mission ranged from 1.9×10 3 n cm −2 (bladder) to 5.1×10 3 n cm −2 (brain) by a factor of 2.7. Based on these data, a probability of HLP hits to a matured cell of each organ or tissue was roughly estimated for a 90-day ISS mission. In the calculation, all cells were assumed to be spheres with a geometric cross-sectional area of 500 μm 2 and the cell-hit frequency from isotropic space radiation can be described by the Poisson-distribution function. As results, the probability of one or more than 1 hit to a single cell by HLP for 90 days ranged from 17% to 38%; that of two or more than 2 hits was estimated to be 1.3 – 8.2%.