Abstract
BackgroundCells respond to a variety of external stimuli regulated by the environment conditions. Mechanical, chemical and biological factors are of great interest and have been deeply studied. Furthermore, mathematical and computational models have been rapidly growing over the past few years, permitting researches to run complex scenarios saving time and resources. Usually these models focus on specific features of cell migration, making them only suitable to study restricted phenomena.MethodsHere we present a versatile finite element (FE) cell-scale 3D migration model based on probabilities depending in turn on ECM mechanical properties, chemical, fluid and boundary conditions.ResultsWith this approach we are able to capture important outcomes of cell migration such as: velocities, trajectories, cell shape and aspect ratio, cell stress or ECM displacements.ConclusionsThe modular form of the model will allow us to constantly update and redefine it as advancements are made in clarifying how cellular events take place.
Highlights
Cells respond to a variety of external stimuli regulated by the environment conditions
The second part shows the effect of the extracellular matrix (ECM) stiffness on the cell stress distribution and cell morphology
The results focus on cell migration, describing trajectories, speeds and directionality for different situations
Summary
Cells respond to a variety of external stimuli regulated by the environment conditions. Mathematical and computational models have been rapidly growing over the past few years, permitting researches to run complex scenarios saving time and resources These models focus on specific features of cell migration, making them only suitable to study restricted phenomena. The way cells migrate and respond to their 3D micro-environment is a multiscale process that results from the integrated effect of the properties of the tissue extracellular matrix (ECM) and the sub-cellular constituents of the cell, mediated by the cytoskeleton (CSK). This integration process depends on multiple mechanical, chemical and biological factors [2,3,4].
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