Abstract

ADV7103 is a galenic formulation of prolonged-release potassium citrate and potassium bicarbonate granules with a simplified twice-daily dosing regimen that has demonstrated better plasma bicarbonate management in patients with distal renal tubular acidosis (dRTA) than standard of care treatments requiring multiple daily intakes, while maintaining normal plasma potassium levels. If not adequately managed, clinical consequences of dRTA include failure to thrive, progressive kidney function decline and bone complications.

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