Pro-inflammatory TNF-α in response to single bout cycling in type II diabetic patients

Abstract

Accumulating evidence suggest that type II diabetes is associated with systemic inflammation. This study aimed to determine relationship between serum TNF-α with glucose and insulin resistance and to evaluate the effect of a single bout moderate exercise on TNF-α in type II diabetes patients. For this purpose, blood samples of pre and immediately post cycling test were collected in order to measuring serum TNF-α, glucose and insulin in twelve adult males with type II diabetes. Insulin resistance was assessed using the homeostasis model assessment for insulin resistance formula derived from fasting insulin and glucose levels. Student’s paired ‘t’ test was applied to compare the pre and post exercise values. Pearson correlation coefficients were used to determine the associations between TNF-α with the blood chemistry parameters. There were no correlations between serum TNF-α concentrations with glucose and insulin and insulin resistance at baseline. Exercise test led to significant increase in TNF-a (p = 0.002) and decrease in glucose concentration (p = 0.000). No significant change were found in insulin (p = 0.154) and insulin resistance at posttest when compared to pretest. Our findings indicate that acute exercise is associated with increased inflammation immediately after test and the change of serum TNF-α by exercise test is independent of glucose or insulin resistance in type II diabetes patients.