Pro-inflammatory cytokines in patients with acute coronary syndrome

Abstract

The pathogenesis of acute coronary syndrome is based on the processes of atherosclerosis of coronary arteries and atherothrombosis, accompanied by the destruction of non-stable atherosclerotic plaque coating and, in the future, by thrombosis. Myocardial ischemia initiates local and systemic inflammatory responses with the release of pro-inflammatory cytokines, which trigger a cascade of reactions, contributing to the more profound damage to cardiomyocytes. That is why it is extremely important to determine the activity of proinflammatory cytokines in patients with acute coronary syndrome.The aim of the work. To investigate the indices of pro-inflammatory cytokines in patients with acute coronary syndrome.Materials and Methods. 33 patients with acute coronary syndrome, namely with unstable angina pectoris, who underwent inpatient treatment in the cardiology department of the Lviv hospital for emergency medicine, were examined. The patients were 12 (36%) males and 21 (64%) females, with an average age of 68.5±2 years. The patients received treatment according to modern protocols for medical care for patients with acute coronary syndrome without ST-segment elevation and recommendations of the European Heart Association. The control group consisted of 20 practically healthy individuals of the same age and status. The patients were subjected to general clinical and instrumental examination methods, proinflammatory interleukins in serum enzyme-linked immunosorbent assay (on admission for hospital treatment).Results of the research. It was found that in patients with acute coronary syndrome, pro-inflammatory cytokines (interleukin-1β, interleukin-6, interleukin-17, tumor necrosis factor-alpha) exceed the values of almost healthy individuals by almost 2 times (p˂0.01).Conclusion. In patients with acute coronary syndrome, there is a significant (p˂0.01) increase in pro-inflammatory cytokines, which indicates the direct involvement of inflammation in the pathogenesis of the pathological process and requires appropriate correction of treatment tactics.