Abstract
ObjectiveTo highlight the inflammatory and immunological mechanisms involved in depression and psoriasis. MethodsA comprehensive literature search was performed in various databases, in total 145 studies were selected. ResultsDepression and psoriasis have an association. Immune mechanisms —the actions of tumor necrosis factor-α, interleukin 1 (IL-1), IL-2, IL-10, IL-22, IL-17, interferon-γ, IL-1β, prostaglandin E2, C-reactive protein, IL-6, and IL-8 etc.—, and some genetic changes are involved. ConclusionsA possible bidirectional relationship of psoriasis and major depression exists; i.e. the depression leads to psoriasis, and psoriasis leads to depression. We recommend more studies in the future to get a deeper and better understanding about this relationship.
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