Pro-Inflammatory Cytokine Concentration in Gingival Fluid in Obese

Abstract

Introduction nbsp High levels of pro inflammatory cytokines both in periodontal disease and in obese people are well documented in the literature However there is weak evidence of the relation between both pathologies and cytokines concentration both in serum as in gingival fluid i e Interleukin and Gamma Interferon The objective of our exploratory study is to measure the concentration of pro inflammatory cytokines such as Interleukin and Gamma Interferon in the gingival fluid of the obese patients with different clinical periodontal status Methods nbsp Twenty one adult patients with a body mass index gt Kg m were included Baseline measurements including clinical parameters and gingival fluid samples were taken to all subjects Gingival fluid sample was taken in order to measure the Interleukin and Gamma Interferon concentrations Results nbsp Nineteen patients had periodontal disease Among them the disease was mild in moderate in and severe in of the patients The average cytokine concentration in gingival fluid for Interleukin was pg ml and for Gamma Interferon pg ml Interleukin concentration in patients with concomitant diseases was pg ml and in those without concomitant diseases was pg ml p the Gamma Interferon concentration was pg ml and in the patients without concomitant diseases pg ml p Conclusion nbsp Even though the strong association between obesity and periodontal disease has been proved the estimation of the persistence of the inflammatory response through the high levels of pro inflammatory cytokines seems to be more related to the concomitant diseases with inflammatory origin disorders than with the association itself