Abstract
A deregulation in blood vessel formation and integrity can lead to a pathological state as seen in many ischemic diseases such as tumor growth, rheumatoid arthritis, psoriasis, retinopathies and atherosclerosis. Therefore, the possibility to modulate regional angiogenesis in patients suffering from ischemia is clinically relevant. One key feature in the induction of pathological angiogenesis is that inflammation precedes and accompanies the formation of neovessels as evidenced by increased vascular permeability and the recruitment of monocytes/macrophages and neutrophils. Previously we, along with other groups have shown that selected growth factors, namely vascular endothelial growth factor (VEGF) and angiopoietins (Ang1 and Ang2) not only promote angiogenesis but also induce inflammatory responses, including the synthesis/release of inflammatory mediators and neutrophil migration. The objectives of our study were to address how VEGF and angiopoietins are capable of promoting the formation of neovessels over time and to assess the role of different inflammatory cells in this event.
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