Abstract
Lipidic α-amino acids (LAAs) have been described as non-natural amino acids with long saturated or unsaturated aliphatic chains. In the continuing prospect to discover anticancer agents from marine sources, we have obtained a mixture of two cytotoxic LAAs ( 1a and 1b) from the zoanthid Protopalythoa variabilis. The anti-proliferative potential of 14 synthetic LAAs and 1a/ 1b were evaluated on four tumor cell lines (HCT-8, SF-295, MDA-MB-435, and HL-60). Five of the synthetic LAAs showed high percentage of tumor cell inhibition, while 1a/ 1b completely inhibited tumor cell growth. Additionally, apoptotic effects of 1a/ 1b were studied on HL-60 cell line. 1a/ 1b-treated cells showed apoptosis morphology, loss of mitochondrial potential, and DNA fragmentation.
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