Abstract
Recently, seaweeds and their extracts have attracted great interest in the pharmaceutical industry as a source of bioactive compounds. Studies have demonstrated the cytotoxic activity of macroalgae towards different types of cancer cell models, and their consumption has been suggested as a chemo-preventive agent against several cancers such as breast, cervix and colon cancers. Reports relevant to the chemical properties of brown algae Padina sp. are limited and those accompanied to a comprehensive evaluation of the biological activity on osteosarcoma (OS) are non existent. In this report, we explored the chemical composition of French Polynesian Padina pavonica extract (EPP) by spectrophotometric assays (total phenolic, flavonoid and tannin content, and antioxidant activity) and by gas chromatography-mass spectrometry (GC-MS) analysis, and provided EPP lipid and sterols profiles. Several compounds with relevant biological activity were also identified that suggest interesting pharmacological and health-protecting effects for EPP. Moreover, we demonstrated that EPP presents good anti-proliferative and pro-apoptotic activities against two OS cell lines, SaOS-2 and MNNG, with different cancer-related phenotypes. Finally, our data suggest that EPP might target different properties associated with cancer development and aggressiveness.
Highlights
Seaweeds and their extracts have attracted great interest in the pharmaceutical industry as a source of bioactive compounds [1].A number of studies have demonstrated the cytotoxic activity of macroalgae towards different types of cancer cell models and certain authors have suggested the consumption of algae as a chemo-preventive agent against several cancers
Brown algae have demonstrated to be rich in unsaturated fatty acids, which block growth and systemic spread of human breast cancer, polysaccharides and terpenoids which are considered as promising bioactive molecules with anticancer activity [2,3]
Padina pavonica is representative of brown algae which can be found throughout the world from warm temperate to tropical locations, including: North Carolina to Florida in the United States, the Gulf of Mexico, throughout the Caribbean and tropical Atlantic and the
Summary
Seaweeds and their extracts have attracted great interest in the pharmaceutical industry as a source of bioactive compounds [1]. A number of studies have demonstrated the cytotoxic activity of macroalgae towards different types of cancer cell models and certain authors have suggested the consumption of algae as a chemo-preventive agent against several cancers. Brown algae have demonstrated to be rich in unsaturated fatty acids, which block growth and systemic spread of human breast cancer, polysaccharides and terpenoids which are considered as promising bioactive molecules with anticancer activity [2,3]. Padina pavonica is representative of brown algae which can be found throughout the world from warm temperate to tropical locations, including: North Carolina to Florida in the United States, the Gulf of Mexico, throughout the Caribbean and tropical Atlantic and the. Mar. Drugs 2018, 16, 504; doi:10.3390/md16120504 www.mdpi.com/journal/marinedrugs.
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