Abstract
Background PRO 2000 is a polyanionic compound under development as a topical antimicrobial gel for the prevention of HIV-1 transmission. PRO 2000 is a synthetic naphthalene polymer which is documented to bind to HIV-1 gp120 and interferes with virus binding to CD4 T cells. Peculiar is that PRO 2000 appears to be more active (~10-fold) in inhibiting X4 viruses (IC50: 1.9 μg/ml) compared to R5 viruses (IC50: 20.8 μg/ml). Therefore, we investigated interactions of PRO 2000 with cellular HIV (co)-receptors.
Highlights
PRO 2000 is a polyanionic compound under development as a topical antimicrobial gel for the prevention of HIV-1 transmission
PRO 2000 is a synthetic naphthalene polymer which is documented to bind to HIV-1 gp120 and interferes with virus binding to CD4+ T cells
PRO 2000 dose-dependently interfered with the binding of several anti-CD4 mAbs and anti-CXCR4 in Peripheral blood mononuclear cells (PBMCs), whereas minor or no effects were observed on DCSIGN and CCR5
Summary
PRO 2000 is a polyanionic compound under development as a topical antimicrobial gel for the prevention of HIV-1 transmission. PRO 2000 is a synthetic naphthalene polymer which is documented to bind to HIV-1 gp120 and interferes with virus binding to CD4+ T cells. Peculiar is that PRO 2000 appears to be more active (~10-fold) in inhibiting X4 viruses (IC50: 1.9 μg/ml) compared to R5 viruses (IC50: 20.8 μg/ml). We investigated interactions of PRO 2000 with cellular HIV (co)-receptors
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