PRM76 - Stated time-allocation, adherence, and health-outcome tradeoff preferences in cystic fibrosis households

Abstract

Objective: To quantify preferences for allocating hypothetical time savings in cystic fi brosis (CF) inhaled-antibiotic treatment among health care and non–health care activities. Methods: Adult patients with a selfreported physician diagnosis of CF and parents of juvenile patients with CF in the United States (US) who have Pseudomonas aeruginosa in their sputum culture at least twice a year completed a Web-enabled, discretechoice experiment survey. Respondents evaluated treatmentchoice and routine-choice alternatives followed by stated adherence for themselves and other people. Questions required evaluating pairs of hypothetical inhalation devices and routine profi les defi ned by inhalation device features, side effects, time spent on inhaled-antibiotic treatment, time spent on hypertonic saline, time spent on other CF-care activities, and lung function measured as forced expiratory volume in 1 second (FEV 1 ). Respondents also answered a question indicating how they would allocate 80 hypothetical minutes of time savings per day among CF-care and non–CF-care activities (work, sleep, family activities, and social activities). Using a conceptual framework describing optimal time allocations within a health production function, random-parameters logit models were used to quantify tradeoff preferences among effi cacy, treatment-time adherence, and competing time demands. Results: The fi nal sample included 174 adult patients and 130 parents. On average, adult patients would spend 9% of the time saved on additional CF-care activities, and the remaining time would be almost evenly split between work, social activities, and sleep. Juvenile patients would spend 11% of the time saved on additional CF-care activities and about 2.5 times more minutes in social activities than in work and 2 times more minutes in social activities than in sleep.