Abstract
PRM7 - Systematic Literature Review and Validity Evaluation of the Expanded Disability Status Scale (EDSS) and the Multiple Sclerosis Functional Composite (MSFC) in Patients with Multiple Sclerosis
Highlights
There are a number of instruments to describe severity and progression of multiple sclerosis, which are increasingly used as endpoints to assess the effectiveness of therapeutic interventions
We examined to what extent the psychometric properties of the two accepted instruments - Expanded Disability Status Scale (EDSS) and MSFC – meet the methodological standards and what value they have in clinical trials
For use in clinical studies, we found that the EDSS has been preferred as a primary and secondary outcome measure in recent studies (50 EDSS, 9 MSFC)
Summary
In these cases logistic or linear models are applied to make the indirect comparisons. Sometimes datasets contain multinomial outcomes, such as ‘complete’, ‘partial’ and ‘no’ response in oncology, that need to be indirectly compared. Different indirect comparisons methods may be required to answer different research questions. Our goal was to identify and qualitatively compare the different techniques that have been used to model multinomial data in an indirect comparison framework. Methods: A systematic review of the PubMed database was conducted to identify different methods for handling multinomial data in a meta-analysis. Models were qualitatively compared according to their assumptions, flexibility and complexity. Results: The systematic review identified three methods: a proportional odds model, an ordered logistic model, and a multinomial model.
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