PRM221 - Network Meta-Analysis for Health Technology Submissions Worldwide: A Report Checklist for Network Meta Analysis Best Practices Globally

Abstract

Network meta-analysis (NMA) represents an important and developing method for Health Technology Assessment (HTA). The aim of this study was to review submission guidelines issued by HTA bodies worldwide and produce a checklist for reporting NMA within HTA submissions globally. The web-based repository of country-specific pharmacoeconomic guidelines maintained by ISPOR was reviewed in January 2015. Guidelines from a number of countries providing sufficient guidance for the use of NMA in HTA submissions were identified and independently reviewed. Following review of the available guidance from a number of countries, a single common checklist was developed. The checklist included recommendations relating to five main themes: data; statistical methodology; analyses performed; presentation of results; and technical issues. This reporting checklist provides practical support to health technology manufacturers enabling them to assess the suitability of NMA reports in meeting the requirements of global HTA bodies. In addition, this checklist can be seen as a valid quality tool to critically appraise the reporting of NMAs within HTA.