Abstract
In today's Lancet, Luisa Gregori and colleagues1 show that an affinity-resin column is capable of removing infectivity associated with endogenous prions from leucofiltered whole blood in a scrapie-infected hamster model. This builds on previous work by this group2,3 and others4,5 showing that prion reduction via filtration could reduce the risk of transmitting variant Creutzfeldt-Jakob disease (vCJD) by blood transfusion. What is the current level of risk and how effective are these devices likely to be?
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