Abstract
AbstractThe demand for fast and ultratrace biomarkers detection is increasing in bioanalytical chemistry. In this work, highly ordered nanowires array and sensor integration are achieved with nanoscale printing approach. Negatively charged poly(3,4‐ethylenedioxythiophene)–poly(styrenesulfonate) doped with positively charged PEGylated biotin‐derivatized polyelectrolytes results a direct biofunctionalization on the nanowire surface without multiple postmodification steps. It provides homogeneous dispersed biofunctional sites and nonfouling surface on the nanowires. The ordered nanowires array enables the immunosensor to detect biotargets quickly and ultrasensitively. The nanowires impedimetric immunosensor is demonstrated for specific biomarkers detection and achieved a minimum responsive concentration as low as 10 pg mL−1 for protein biomarker and 10 CFU mL−1 for pathogen.
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