Principles, Processes and Modalities of Interaction Between Proto-Oncoprotein PIM-1 Kinase and Cell Division Cyclin CDC25A

Abstract

All malignant tumors with aberrant cell differentiation and proliferation, unchecked growth, invasion, and metastasis are referred to as cancer. Its occurrence is a multi-step, complex process with many contributing components. Proto oncoprotein and The PIM kinase family is crucial to this procedure., and proto oncoprotein PIM-1 kinase is an important member of PIM family. The expression of proto oncoprotein PIM-1 is positively correlated with the status of lymphatic metastasis, and its overexpression could promote cell cycle and inhibit apoptosis. Cell division cycle 25 (CDC25) is a bispecific phosphatase from Schizosaccharomyces cerevisiae in 1986. CDC25 can activate CDK by catalyzing the dephosphorylation of inhibitory phosphorylation sites in the cell cycle dependent protein kinases (CDK) molecule, and regulate the response to DNA damage, thus promoting cell cycle operation. The interaction between the proto oncoprotein CDC25A in the above process is one of the keys to the current mechanism research with PIM-1 kinase. In this paper, PIM-1 and CDC25 are first introduced, respectively. Then, the interaction between PIM-1 and different substrates with a focus on CDC25A is presented. Finally, their role in tumor initiation and the application of CDC25A as a therapeutic target are highlighted. Therefore, this paper will discuss the interaction between CDC25A and PIM family.