Abstract
The most detailed information about the structural and functional characteristics of the muscle can be gained from the single motor unit (MU) action potential. In addition, information about the activity of a single MU is essential for the diagnosis of neuromuscular disorders. Due to the low spatial resolution of conventional bipolar surface electromyography (EMG), the resulting signal is a superposition of a large number of simultaneous active MUs. The difficulty is in separating the activity of a single MU from simultaneous active adjacent MUs. In contrast to other non-invasive EMG procedures, the high-spatial-resolution-EMG (HSR-EMG), which is based on the use of a multi-electrode array in combination with a spatial filter procedure, allows the detection of single MU activity in a non-invasive way. It opens access to the excitation spread and enables the determination of the conduction velocity in single MUs, and the localization of the endplate region. In addition, HSR-EMG detects changes in the electrical activities of the MUs which are typical in neuromuscular disorders. Using HSR-EMG it was possible to identify 97% of all investigated volunteers and patients with muscular or neuronal disorders. Therefore, HSR-EMG is suitable as a tool for the non-invasive diagnosis of neuromuscular disorders.
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