Abstract
Aim. The presented research uncovers the using of mathematical modeling methods for cardio-vascular system and axial blood pump interaction analysis under heart failure with combined valve pathology. The research will pro- vide data for automated pump control algorithm synthesis. Materials and methods. Mathematical model is build up by using experiments results from mock cardio-vascular circulation loop and mathematical representation of Newtonian fl uid dynamics in pulsing circulation loop. The model implemented in modeling environment Simulink (Matlab). Results. Authors implemented mathematical model which describe cardio-vascular system and left-ven- tricular assistive device interaction for intact conditions. Values of parameters for intact conditions were acquired in the experiments on animals with implanted axial pump, experiments were conducted in FRCTAO. The model was veri fi ed by comparison of instantaneous blood fl owrate values in experiments and in model. Conclusion. The paper present implemented mathematical model of cardio-vascular system and axial pump interaction for intact conditions, where the pump connected between left ventricle and aorta. In the next part of research authors will use the presented model to evaluate using the biotechnical system in conditions of heart failure and valve pathology.
Highlights
ИСКУССТВЕННЫЕ ОРГАНЫДанное исследование посвящено применению методов математического моделирования для анализа взаимодействия сердечно-сосудистой системы и осевого вспомогательного насоса в условиях сердечной недостаточности при сочетанной клапанной патологии на этапах подключения насоса
The paper present implemented mathematical model of cardio-vascular system and axial pump interaction for intact conditions, where the pump connected between left ventricle and aorta
Clinical outcomes are similar in pulsatile and nonpulsatile left ventricular assist device recipients
Summary
Данное исследование посвящено применению методов математического моделирования для анализа взаимодействия сердечно-сосудистой системы и осевого вспомогательного насоса в условиях сердечной недостаточности при сочетанной клапанной патологии на этапах подключения насоса. Aim. The presented research uncovers the using of mathematical modeling methods for cardio-vascular system and axial blood pump interaction analysis under heart failure with combined valve pathology. The paper present implemented mathematical model of cardio-vascular system and axial pump interaction for intact conditions, where the pump connected between left ventricle and aorta. Bykov Ilya Viktorovich – graduate student, laboratory of biotechnical systems (Head – professor G.P. Itkin), Academician V.I. Schumakov federal research center of transplantology and artificial organs Одной из возможных причин этого является отсутствие экспериментальных исследований взаимодействия сердечно-сосудистой системы и ВНК в условиях моделирования тяжелых форм сердечной недостаточности, вызванной как снижением сократительной способности миокарда, так и сопутствующей клапанной патологии. Для выполнения описанных выше требований к модели было решено использовать структурную схему, изображенную на рис. 1
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