Abstract
Abstract In the aged dog and cat, especially dog, a cognitive decline develops naturally in many different domains, but at the same time it also exhibits human-like individual variability in the aging process. In the aging dog and cat brain lesions develop spontaneously. Dogs share some morphological characteristics with those of Alzheimer’s disease in man. The canine brain with its plaques and tangles which show oxidative changes, forms a spontaneous model for understanding the early changes and their interrelationships in Alzheimer’s disease. Additionally, the aged dog represents a useful model for the development of preventive or therapeutic interventions to improve aged brain function. These interventions can then be translated into human clinical trials.
Highlights
In the aged dog and cat, especially dog, a cognitive decline develops naturally in many different domains, but at the same time it exhibits human-like individual variability in the aging process
Most of these principles have evolved over decades and represent the basis of our current concept on neuropathology
With respect to the CNS, a statement can be made that applies to all diseases of humans and animals: some disorders are highly comparable, some share some points of similarity, and others are limited to humans or to individual animal species
Summary
In the aged dog and cat, especially dog, a cognitive decline develops naturally in many different domains, but at the same time it exhibits human-like individual variability in the aging process. Neuronal lipofuscinosis in the aged human being and the enderly dog are probably analogous conditions, whereas the full neuropathological spectrum of Alzheimer’s disease is not encountered spontaneously in any of the domestic animals. In general terms can we compare the brain of an aged human with an aged dog or cat.
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