Abstract
Background: Currently there are no tests to assist in selecting the optimal preoperative chemotherapy (Primary Systemic Therapy, PST) regimens for breast cancer patients. Primary study goals of this prospective, single-armed multicentric investigation are pathologically confirmed tumour response and the rate of breast conserving therapy (BCT). Secondary study goals are to find histopathologic and gene profiling patterns best correlating with tumour remission in a taxane- anthracycline based neoadjuvant setting as well as to evaluate cytostatic toxicity and quality of life.
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