Abstract
Dendritic Cells In our immune systems, T follicular helper (Tfh) cells modulate antibody production by B cells. Krishnaswamy et al. examined the ability of conventional dendritic cell (cDC) subsets to prime Tfh commitment in response to intranasal immunization in mice. CD11b+ migratory type 2 cDCs (cDC2s) played an essential role in promoting commitment of activated T cells to the Tfh lineage. The authors imaged trafficking of cDC2s after intranasal immunization and found that they carried antigens to the site within the lymph node where Tfh cell priming occurs. These findings have important implications for vaccine design and delivery. Sci. Immunol. 2 , eaam9169 (2017).
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