Abstract

This clinical update addresses first-episode psychosis (FEP), a clinical disorder in which a patient experiences psychotic symptoms such as delirium, hallucinations, and/or disorganized thinking for the first time. The clinical manifestations of FEP are highly varied and it is common to find other types of accompanying signs and symptoms. Psychotic experiences are highly prevalent in the general population and can occur in a wide range of situations that range from normality to severe psychotic disorders. When a diagnosis of FEP is suspected, it is crucial to conduct a detailed assessment of the impact and intensity of the symptoms, an adequate differential diagnosis, and close monitoring of the case. FEP usually occurs in people aged 15 to 35 years and has a significant impact on the patient's life. Multifactorial in its etiology, FEP entails a challenge for research in the areas of psychiatry and neurosciences. Some factors related to its onset have been described and, due to their possible causal role, they are of particular interest for future preventive or treatment interventions. In addition to pharmacological treatment, a multidisciplinary intervention that involves different professionals and is conducted in specialized units for treating FEP are recommended.

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