Abstract
This is a case report of a patient who underwent Oxaliplatin based neo-adjuvant chemotherapy for colorectal liver metastases, and subsequently developed sinusoidal obstruction, which was detected by Primavist enhanced MRI scan.
Highlights
This is a case report of a gentleman who was initially diagnosed with and sigmoid colon carcinoma, and subsequently treated with a sigmoid colectomy in December 2008
This is a case report of a patient who underwent Oxaliplatin based neo-adjuvant chemotherapy for colorectal liver metastases, and subsequently developed sinusoidal obstruction, which was detected by Primavist enhanced MRI scan
Oxaliplatin is a cytotoxic platinum compound, originally discovered by Professor Yoshinori Kidani at the Nagoya City University. It exerts its action by cross linking DNA strands, thereby, preventing division and replication. It is primarily used in the treatment of advanced colorectal carcinoma which has metastasised to local/regional lymph nodes as part of the FOLFOX regime (Folic acid, 5-FU and Oxaliplatin)
Summary
This is a case report of a gentleman who was initially diagnosed with and sigmoid colon carcinoma, and subsequently treated with a sigmoid colectomy in December 2008. This is a case report of a patient who underwent Oxaliplatin based neo-adjuvant chemotherapy for colorectal liver metastases, and subsequently developed sinusoidal obstruction, which was detected by Primavist enhanced MRI scan. In February 2009, the patient underwent a repeat CT scan, which demonstrated that new metastases had appeared in the liver, and had made the lesions non-resectable.
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