Primary yolk sac tumor of seminal vesicle: a case report and literature review

Xu-Dong Yao,Chao-Fu Wang,Ding-Wei Ye,Ya-Ping Hong

doi:10.1186/1477-7819-10-189

Xu-Dong Yao, Chao-Fu Wang + Show 2 more

Open Access

https://doi.org/10.1186/1477-7819-10-189

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Abstract

BackgroundYolk sac tumor (endodermal sinus tumor) is a rare malignant germ cell tumor arising in the testis or ovary. Extragonadal yolk sac tumor is even rarer and has only been described in case reports. Due to the rarity of the tumors, the appropriately optimal treatment remains unclear. We report a case of yolk sac tumor in the seminal vesicle.CaseA 38-year-old Asian male presented with gross hematuria and hemospermia. Transrectal ultrasound scan showed a solid mass in the left seminal vesicle and the scrotal sonography showed no abnormalities. Bilateral seminal vesicles were resected, and histopathological examination showed a typical pattern of yolk sac tumor (YST). The patient responded poorly to comprehensive treatment of radiotherapy, chemotherapy and surgeries, developed systemic multiple metastases, and died of cachexia one and half years after diagnosis.

Highlights

Yolk sac tumor is a rare malignant germ cell tumor arising in the testis or ovary
To add to the literature, we report a case of yolk sac tumor originating in the left seminal vesicle
Case presentation A 38-year-old Asian male presented to his urologist with gross hematuria and hemospermia of a half-year duration

Summary

Introduction

Yolk sac tumor (endodermal sinus tumor) is a rare malignant germ cell tumor arising in the testis or ovary. Extragonadal yolk sac tumor (YST) is rare, and the most common sites of origin are, in order of frequency, the mediastinum, the retroperitoneum, the sacrococcygeal region and the pineal gland [2]. To add to the literature, we report a case of yolk sac tumor originating in the left seminal vesicle. * Correspondence: yaoxudong67@sina.com †Equal contributors 1Department of Urology, Fudan University Shanghai Cancer Center, 270 Dong’an Road, Shanghai 200032, China Full list of author information is available at the end of the article day of presentation showed a solid mass of the left seminal vesicle.

Results

Conclusion