Abstract
The study was conducted to explore the prevalence of thyroid autoimmune disorders among primaryinfertile women. Hormonal and immunological serum markers were tested including: TSH, T3, T4, TPO Ab,prolactin and Interleukin-6. Thyroid abnormalities were observed in 38.5% of the primary infertile women.Thyroid autoimmunity was more prevalent among primary infertile women (9.6%) than pregnant (4.0%)and non-pregnant (4.3%) fertile women, but with no significant difference. Presence of thyroid hormonesrelated clinical manifestation in infertile women was higher (26.9%) in comparison to pregnant fertilewomen and non-pregnant fertile groups. Abnormalities in menstrual cycles were much higher in infertilewomen (90.4%) than non-pregnant fertile women (27.7%). Serum level of IL-6 was with no significantdifferences among all study groups. In conclusion, AITD has a minor participation in the thyroid disorder–associated infertility and their menstrual abnormalities in comparison with the larger scale of the non-AITDparticipation. No role for the IL-6 in the thyroid associated primary infertility in women was detected.
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