Abstract

Abstract Primary urethral cancer is a rare but highly aggressive malignancy. Risk factors include chronic inflammation and irritation of the urethra. In early stages, this type of cancer presents with nonspecific symptoms, which can be misleading and associated with urethral strictures. We report a case of a 66-year-old male with a history of urethral stricture who presented with a perineal abscess of unknown origin. During the process of treatment, he was diagnosed with primary urethral carcinoma. Salvage therapy immediately followed, including surgery and radiation, but during the follow-up, the patient developed distant metastases and died 2 years after initial diagnosis.

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