Abstract
The features of 192 primary thymic tumours occurring in the rat are described. Of these neoplasms, 170 were classified as benign thymomas, one as a benign fibrous histiocytoma, 20 as various types of malignant thymoma, 3 lympho-epithelioma-like carcinomas, one mixed small cell undifferentiated-squamous cell carcinoma, one sarcoma-like carcinoma, 4 undifferentiated carcinomas, 11 squamous cell carcinomas and the one remaining tumour as a carcinoid. A mouse, anti-epithelial, monoclonal antibody, lu-5, was used to confirm the epithelial nature of the malignant thymomas, and neuron-specific enolase to confirm the diagnosis of carcinoid. The tumours showed many features in common with those reported in man.
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